Granulation has many advantages including dust free formulation's, improved flowability,stability, eliminates poor content uniformity, improved bioavailability of API to name a few.
During wet granulation, liquid binders or adhesives are added to the lactose and active mixture, usually by blending. The mixture is then dried and sized, and compressed into tablets. There by producing a dust free formula plus improving flowability, eliminating poor content uniformity and the ability to encapsulate a poorly soluble API.
During dry granulation, the particle size is enhanced by aggregating the particles by roller compaction and then milling to the desired size, resulting in improved content uniformity, dissolution times, and stability.
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