Wet and Dry Granulation
During wet granulation, liquid binders or adhesives are added to the lactose and active mixture, usually by blending. The mixture is then dried and sized, and compressed into tablets.
During dry granulation, the particle size is enhanced by aggregating the particles by roller compaction and then milling to the desired size.
Advantages of Granulation - Produce dust free formula
- Improve flowability
- Eliminate poor content uniformity
- Improve tablet solubility – dissolution
- Manipulate bulk density
- Improve stability
- Improve bioavailabilty of API
- Encapsulate poorly soluble API
|  |
Select the lactose that fits your application
*controlling the granulation is very difficult. Only use with very little water addition and fast process to avoid transformation to Monohydrate and/or Alpha lactose
Contact us for application and formulation assistance