Direct Compression
In the direct compression method of tablet production, dry ingredients are thoroughly mixed and then compressed into tablets. This eliminates the drying steps associated with the wet granulation method. It also reduces the higher costs involved in wet granulation including increased equipment, labor, time, process validation and energy expenditure.
As a result, direct compression is both efficient and economical, well suited to the production of high quality tablets, which exhibit hardness, low friability and excellent dissolution rates. As an added benefit, direct compression can improve the physical and chemical stability of tablets as compared to wet granulation Bolhius and Lerk, 1973).
Advantages - More cost effective than Wet Granulation
- Less processing steps equals better consistency
- No water addition to affect moisture sensitive APIs
- Less excipients – eliminate superdisintegrants
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Direct compression demands the use of excipients with strictly defined properties. Sheffield™ Bio-Science has designed a range of excipients specifically to meet the requirements of the direct compaction process and your needs
Contact us for application and formulation assistance