Welcome to Sheffield Bio-Science

Chemically Defined Metabolic Enhancers for use with a variety of cell lines

Sheffield's Chemically Defined Supplements are animal-component free supplements for use with a variety of cells, and were developed for use in complete media with or without nutritive feeds. Composed of small molecules that direct cellular pathways and does not provide basic nutritional factors, such as insulin, cytokines, amino acids, and glutamine. 

Sheffield's chemically defined supplements for mammalian cell culture were developed by bioprocess engineers to improve cell culture performance and to enhance protein production while maintaining cell viability, effectively increasing overall bio-manufacturing efficiencies. They are commercially available for use with a variety of cell lines. 

Contact us to learn how these systems can compliment the well-established yield improvements achieved by using hydrolysates, rAlbumin, rInsulin CC, and yeast extracts.